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Research Scientist II MS Biophysics

Company: Takeda Pharmaceutical
Location: Poway
Posted on: August 7, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description The Drug Discovery Sciences (DDS) department at Takeda is seeking a talented mass spectrometrist to design, develop, and implement MS experiments to support drug discovery projects aimed at the identification, validation and characterization of small molecules interacting with biomolecular targets, including proteins and RNAs. You will implement various MS approaches including MS-based HTS strategies (ASMS), Native MS, Ion mobility MS, peptide mapping, HDX- depending on project needs.You will collaborate with internal and external partners to accelerate drug discovery programs in the areas of Oncology, GI, Neurosciences and Rare Diseases. You should have a track record in the characterization of small molecules interactions with proteins and RNAs and the use of MS methods to drive compound optimization.

  • Manage the design, development, and implementation of MS experiments to support drug discovery projects, and characterize small molecule interactions with potential drug targets (proteins and RNAs)
  • Must possess extensive experience and understanding of various MS approaches including peptide mapping strategies, ASMS, Native MS and Ion mobility MS, HDX.
  • Operate and maintain different types of mass spectrometers, including a Q Exactive Orbitrap coupled with LEAP PAL2 robot and QTOF coupled with HPLC, 2D-LC Q-TOF instruments (agilent infinity-II, 6530C Q-TOF jet stream etc)
  • Proficient in using MS analysis software (e.g. masshunter, virscidian)
  • Perform quantitative mass spectrometry based strategies including isotopic labeling, SILAC, and label-free analysis
  • In-depth understanding of qualitative and quantitative protein analyses using chromatography and high-resolution mass spectrometry with advanced data interpretation skills
  • Broad-based understanding of drug discovery for a variety of drug modalities (small molecule, proteins, degraders, antibodies, antibody-drug-conjugates,etc.)
  • Work closely with other biophysicists to develop integrative approaches to address specific challenges and bottlenecks.
  • Identify, manage and lead collaborations with partners (academic, biotech and CRO) to enhance in-house capabilities.
  • Participate on cross-functional teams, and provide technical leadership in the areas of mass spectrometry.
  • Effectively present data to other scientific staff and cross-functional project teams; may present data/posters to external research or scientific community.
  • Initiates and leads external interactions and collaborations
  • Frequent contact with internal and external personnel at various management levels
  • Collaborates with other departments, and disciplines, acting as scientific authority withindiscipline
  • Serves as senior company / project representative at external conferences, or business meetings EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
    • PhD degree in a scientific discipline (or equivalent) with 2+ years relevant experience, or MS with 8+ years relevant experience, or BS with 10+ years relevant experience
    • Strong background in peptide mapping strategies, and well versed in other MS techniques such as ASMS, Native MS and Ion mobility MS. HDX would be considered a plus.
    • Demonstrates fundamental understanding of drug discovery within one or more areas.
    • Experience in protein/RNA interaction studies as well as a good understanding of other biophysical techniques like TSA, SPR, ITC, DLS and fluorescence spectroscopy.
    • Strong track record for studying protein interactions and macromolecular complexes as evidenced by quality and quantity of publications/presentations/inventions.
    • Familiar with other structural biology methods like X-ray crystallography, NMR spectroscopy and electron microscopy.
    • Good team player with positive attitude and strong collaboration skills including the ability to work individually as well as part of an effective team.
    • Highly motivated and flexible with the ability to work in a fast-paced environment. Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
    • Detail oriented and with very high scientific standards.
    • Professionally represent the organization in collaborations, partnership discussions and external relationships and conferences.
    • Proven track record of scientific contributions in life science as evidenced by quality and quantity of publications/presentations/inventions and/or products and clinical candidatesIn accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, Poway , Research Scientist II MS Biophysics, Other , Poway, California

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